Grape seed extract, rich in polyphenols, is an effective remedy for combating inflammatory processes and oxidative stress in calves. Studies show that this plant compound has powerful antioxidant properties, contributing to the improvement of the overall health of young cattle.

One of the key points is the ability of grape seed extract to reduce the level of inflammation in the body of calves. The polyphenols in the extract exhibit anti-inflammatory properties, which is especially important in the initial periods of animal life, when they are exposed to various stresses.

Another important aspect is the ability of polyphenols to protect cells from oxidative stress. This type of stress can occur as a result of adverse conditions of detention, malnutrition or diseases. Grape seed extract helps to reduce the level of free radicals in the body of calves, which helps to maintain their health.

The addition of grape seed extract to the calves' diet can be especially useful in industrial cattle breeding, where it is important to ensure optimal conditions for the growth and development of animals. It is important to monitor the dosage and consult with a veterinarian for optimal results.

Thus, grape seed extract is a promising tool for mitigating inflammatory processes and combating oxidative stress in calves, contributing to maintaining their overall health at an early age.

• GASTROINTESTINAL HEALTH - Phytobiotics help strengthen the rumen microbiota by improving digestion and nutrient absorption in cattle.
• REDUCTION OF INFLAMMATION - Active substances of plant origin in phytobiotics reduce inflammatory processes in the body of cattle, contributing to overall health.
• ANTIOXIDANT PROTECTION AND IMMUNITY - Phytobiotics have antioxidant properties, helping to reduce oxidative stress and maintain the health of animal cells. The immune system is strengthened, which contributes to resistance to various infections.
• ECOLOGY - The use of phytobiotics contributes to the elimination of the preventive use of antibiotics in animal husbandry.

Grape seed extract as a feed additive improves growth rates, scar fermentation and immunity of well-fed bulls. The results obtained during the research show that grape seed extract as a feed additive led to a significant improvement in growth rates, fermentation in the rumen, antioxidant capacity and immunity of weaned calves of meat hybrids.

Phytobiotic FARMAVIO - is a feed additive containing grape seed and skin extract, which acts as an antioxidant. The main action of antioxidants is the neutralization of free radicals to protect healthy cells from damage. Phytobiotic has not only high antioxidant activity, but also helps other antioxidants (vitamins E and C) to restore their structure, thereby reducing their consumption and increasing the availability of vitamins E and C for other biological processes in the body (participation in reproductive function, etc.).

Studies show that the inclusion of phytobiotics from grape seeds and skins in the diet of pigs leads to a noticeable increase in productivity. For example, the survival rate when using these phytobiotics can increase up to 95%, which is a significant improvement over traditional breeding methods.

The analysis of digestive efficiency also reveals positive results. Pigs consuming a diet with phytobiotics from grape seeds and skins show increased weight gain, which ultimately affects the economic efficiency of pig farming. The increase in the average daily growth can reach 15-20%, depending on the growing period.

Equally important is the improvement of pig health under the influence of phytobiotics. Reducing the incidence of diseases and reducing the need for medicines leads to a significant reduction in the cost of veterinary care. Research indicates a reduction in veterinary costs by up to 30%, which is a significant economic benefit for pig farmers.

Moreover, the analysis of statistics shows that the use of phytobiotics from grape seeds and skins reduces the impact on the environment. Fewer medicines used and improved pig digestion reduce soil and water pollution, which meets modern requirements for environmental sustainability in agriculture.

In production experiments in northern Spain on pigs of the Pietren breed, it was found that in experimental groups that were injected with phytobiotics from grape seed and skin in a dose of 2 kg /t of feed, the mortality of piglets during the fattening period was 0.9%, whereas in the experimental group, which was injected with 99% benzoic acid in the amount of 5 kg / ton of feed, the death of piglets was 2.7%. The feed conversion in the experimental group with phytobiotic was 9.44% less than in the group with benzoic acid.

In another production experiment on fattening piglets of Pietren in the amount of 1,500 heads per group, it was found that the addition of a phytobiotic from grape seed and skin at a dose of 2 kg /t of feed reduces piglet mortality by 1.81%, feed conversion by 0.8%, while the average daily live weight gain increased by 3.2%.

Numerous experiments have been conducted on the territory of Italy, which show that the addition of phytobiotics from grape seed and skin in a dose of 2 kg/t in the pre—start and start period, 1.5 kg/t in the grover and 1 kg/t in the finishing period makes it possible to increase safety by 1.5-3.4%, average daily live weight gains — by 4.6-9.8% and reduce feed conversion by 2.5-4.7%.

Thus, the use of phytobiotics from grape seed and skin in pig breeding and rearing demonstrates not only noticeable improvements in animal care, but also in the economic and environmental sustainability of pig farming.

• IMMUNITY - The high content of antioxidants helps strengthen the immune system of pigs.
• GROWTH AND DEVELOPMENT - Contains beneficial trace elements such as iron and zinc, which affect the growth and development of pigs. It can also have a positive effect on the quality of meat, making it more nutritious.
• SKIN AND COAT - Improvement of the general condition of pig skin and coat due to the presence of unsaturated fatty acids in phytobiotics.
• ECOLOGY - The use of phytobiotics from grape seeds and skins in the diet of pigs can reduce the overall dependence on chemical additives, which is important for those who prefer natural and organic methods in pig farming.

In modern horse breeding, innovative approaches to improving the health of horses are constantly being sought. One of these approaches is the use of grape seed and skin extract with antioxidants in the diet of horses. This method helps to improve immunity, maintain the health of hooves and fur, and prevent various diseases. In this article, we will consider the advantages of using grape seed extract for horses.

Antioxidant and its effect on horse health:
Antioxidants from grape seed and skin play a key role in the fight against free radicals, preventing oxidative processes in the body of horses. Studies show that the inclusion of an antioxidant in the diet of horses helps to reduce the risk of inflammatory processes, which is important for ensuring a long and active life of animals.

Improvement of hoof and coat condition:
Statistics show that horses consuming phytobiotics from grape seed and skin have a noticeable improvement in hoof and coat condition. The gloss level of the coat increases, and the condition of the hooves becomes healthier. This is due to its antioxidant properties, which contribute to maintaining an optimal condition of the skin and hair.

Disease prevention:
Studies conducted in veterinary clinics show that the use of grape seed extract and skin in the diet of horses reduces the incidence of diseases. The systematic administration of this antioxidant reduces the number of cases of respiratory diseases and joint problems, which significantly reduces treatment costs and increases the life expectancy of horses.

Economic efficiency:
Cost-benefit analysis shows that investments in the use of phytobiotics from grape seeds and skins pay off in a short time. Reducing the cost of treatment and increasing the life expectancy of horses leads to cost savings and increased efficiency of horse breeding.

• ENERGY - Grape seed and skin extract is one of the most powerful antioxidants. It is 20 times stronger than vitamin C and 50 times stronger than vitamin E.
• BLOOD CIRCULATION - Grape seed and skin premixes act as a vasodilator, helping to open blood vessels and relax the muscles of the circulatory system to facilitate blood flow, providing effective delivery of nutrients and oxygen, as well as reducing capillary pressure.
• HIGH PERFORMANCE - Grape seed and skin extract reduces the effects of lactic acid accumulation and helps in post-competition recovery, ensuring maximum physical fitness for your athletic horses.
• WELLNESS SUPPORT - Grape Seed and Skin Premixes are the perfect antioxidant supplement to provide overall wellness support for your horse's unique needs, whether for athletic horses, older horses, or horses in recovery.

Links to primary sources:
- Smith, J. et al. "The Impact of Grape Seed Antioxidant Supplementation on Equine Health." Journal of Equine Veterinary Science, vol. 25, no. 2, 2022, pp. 87-95. [doi:10.1016/j.jevs.2021.12.005]
- Veterinary Medicine Association. "Antioxidant Use in Equine Nutrition: A Comprehensive Review." Journal of Veterinary Nutrition, vol. 18, no. 4, 2021, pp. 213-225. [doi:10.1080/19490172.2021.1345678]

In conclusion, the use of grape seed and skin extract for horses is a reasonable and promising approach in the field of horse breeding. Statistical data and scientific research confirm its positive impact on the health, well-being and productivity of horses.

Commercial fish farming is a complex process, and effective management of fish health care is becoming an increasingly important aspect of aquaculture. In recent years, phytobiotics, biologically active substances from plants, have attracted attention as a potential means to improve the immunity and productivity of fish in industrial cultivation conditions.
One of the key benefits of phytobiotics is their ability to support the gut microbiota of fish. Healthy intestinal microflora plays an important role in digestion, nutrient absorption, and immune system maintenance. Phytobiotics, such as plant extracts and essential oils, contribute to the balance of microflora, reducing the risk of diseases and improving food absorption.

Another important aspect is the antioxidant activity of phytobiotics. Fish in industrial conditions can be subjected to oxidative stress due to high population density, changes in the aquatic environment and other factors. Phytobiotics help reduce free radical levels, protecting fish cells and contributing to their overall well-being.

The effectiveness of phytobiotics is also manifested in improving the growth and conversion of feed in fish. Some plant extracts promote the absorption of nutrients, which affects the efficiency of feed use and, as a result, an increase in production. The use of modern immunostimulating drugs based on probiotics, prebiotics and phytobiotics is promising for the creation of new feed additives for aquaculture. New feed additives stimulate the growth and development of animals without adversely affecting the physiological state of the body. At the same time, the preparations introduced into the feed can not only positively affect the growth and productivity of fish, but also are environmentally safe additives (Petrusha Yu.K. et al., 2022; Ushakova NA et al., 2021).

Nhu TQ and colleagues (2019) described that grape seed and skin contain a wide range of active substances - alkaloids, steroids, phenols, tannins, terpenoids, saponins, glycosides and flavonoids. These substances contributed to the stimulation of the biological activity of fish, including increased growth, stimulated appetite, enhanced antimicrobial and anti-stress effects. Previous studies have also shown that plant extracts have successfully increased fish immunity and disease resistance (Na-Phatthalung P et al., 2018; Rahman ANA et al., 2018) by increasing immune parameters and controlling infectious diseases by reducing side effects.

Phytobiotics do not have a negative effect on the animal body (Bagno O.A. et al., 2018). Such feed additives based on plant components can become an alternative to antibiotics, improve the health of the body, and increase resistance to pathogenic diseases (Rezende RAE et al., 2021).

Several studies have been conducted on the effect of various herbal feed additives on the body of fish, as a result of which it was revealed that herbal components are safe and effective additives that have a therapeutic effect. For example, in studies conducted by Rezende RAE together with colleagues (2021), a mixture of thyme and rosemary essential oils was used as a phytobiotic, which was injected into extruded feed and fed to juveniles of the Nile tilapia (Oreochromis niloticus) for three weeks. According to the results, a slight increase in body weight of juvenile tilapia relative to the control was noted - by 3.61%. At the same time, at the end of the experiment, the scientists noted that the phytobiotic is able to increase the survival rate of juveniles when exposed to Aeromonas hydrophila on fish: the survival rate was 96.4%. These results show that the phytobiotic feed additive is capable of affecting pathogenic microorganisms. It is worth noting that the introduction of phytobiotics has demonstrated potential benefits for the immune system, contributing to improved biochemical reactions, increased resistance to pathogens and ensuring survival after exposure to Aeromonas hydrophila (Rezende RAE et al., 2021).

When using a phytobiotic consisting of a mixture of essential oils from carvacrol, thymol, and cineol, an increase in dry matter in the muscles of sturgeons by 1.26 times was noted in the feeding of Lena sturgeon (Acipenser baerii). The levels of protein and fat were 1.20 and 1.8 times higher compared to the control group, respectively (Koshak J. et al., 2021).

• IMMUNITY - Phytobiotics activate the immune system of fish and shrimp, making them more resistant to infections and diseases. This reduces the risk of mass diseases in industrial aquaculture;
• GROWTH AND SURVIVAL - The growth of fish and shrimp is stimulated, which is an important aspect in industrial breeding. The survival rate of juveniles increases by reducing stress levels, providing more favorable conditions for their breeding;
• DIGESTIVE SYSTEM - Helps optimize digestion by improving the condition of the gastrointestinal tract and preventing digestive problems;
• ECOLOGY - The need for antibiotics and chemical additives is reduced, which contributes to the environmentally sustainable farming of fish and shrimp, reducing the negative impact on the environment.